A few I've picked up:
1) The project/file view on the right allows you to navigate with arrow keys, but ENTER doesn't open the file.
2) CTRL-S doesn't work on a new file (IE: Untitled).
3) Still quite a few cases were intelli-sense doesn't display.
4) File Open As Hex doesn't work at all for me.
5) What happened to the record/play macro functionality?
6) File Open, doesn't allow you to select multiple files.