I have tracked down the time lag that JJ mentioned. I downloaded the vs 2017 release candidate enterprise edition (all 15 gig of it) and climbed through an archipelago of directories,
C:\Program Files (x86)\Microsoft Visual Studio\2017\Enterprise\VC\Tools\MSVC\14.10.24930\bin>
And found the usual 2 different versions of ML64. The version under "hostX64" is larger and probably a 64 bit version. It had some seconds delay before it will build a simple x64 app. The version under "hostX86" is smaller and probably a 32 bit executable but its much faster than the other and builds 64 bit MASM file just fine.
Here is a simple demo of picking the right version of ML64 for Windows 10 64 bit. Clean simple 64 bit MASM code.

; ¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤
include \masm32\include64\masm64rt.inc
.code
; ¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤
entry_point proc
conout lf,"Hi hi hi, I am a console app built with",lf, \
"ML64 version 14.10.24930.0 from VS 2017",lf, \
"on Windows version 10 professional 64 bit",lf,lf
waitkey
invoke ExitProcess,0
ret
entry_point endp
; ¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤
end
Build output.
Microsoft (R) Macro Assembler (x64) Version 14.10.24930.0
Copyright (C) Microsoft Corporation. All rights reserved.
Assembling: console.asm
Volume in drive K is disk3_k
Volume Serial Number is 68C7-4DBB
Directory of K:\asm64\console
02/21/2017 02:20 PM 590 console.asm
02/21/2017 02:23 PM 4,096 console.exe
02/21/2017 02:23 PM 2,526 console.obj
3 File(s) 7,212 bytes
0 Dir(s) 973,757,313,024 bytes free
Press any key to continue . . .
App output.
Hi hi hi, I am a console app built with
ML64 version 14.10.24930.0 from VS 2017
on Windows version 10 professional 64 bit
Press any key to continue...
Cruel ain't it. :P