OK, I'll weigh in..
AMD A6-9220e RADEON R4, 5 COMPUTE CORES 2C+3G
fast Instr_ at 1599980007: 288 ms
slow Instr_ at 1599980007: 1856 ms
Masm32 find$ at 1599980007: 1864 ms
CRT strstr at 1599980006: 1948 ms
case-insensitive:
fast Instr_ at 1599980001: 289 ms (only first character case-insensitive)
slow Instr_ at 1599980001: 1851 ms (full case-insensitive search)
StrStrIA at 980000: 266 ms (shortened because it's utterly slow)
Windows 7 Pro, 32 bit btw.